Premium
Effects of EMD 15,700 and disulfiram on ethanol intake in rats under schedule‐induced polydipsia
Author(s) -
McMillan D. E.
Publication year - 1983
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430030211
Subject(s) - polydipsia , ethanol , disulfiram , chemistry , alcohol , aldehyde dehydrogenase , water intake , acetaldehyde , water consumption , zoology , endocrinology , pharmacology , food science , medicine , biochemistry , biology , enzyme , engineering , diabetes mellitus , waste management
Abstract Rats received 196 food pellets per day under a fixed‐time 90‐sec schedule with both 5% (w/v) ethanol and water freely available. More than 80% of the total daily fluid consumption was the 5% ethanol solution. Disulfiram, and a new aldehyde dehydrogenase inhibitor, EMD 15,700, both markedly decreased 5% ethanol intake and slightly increased water intake. These effects lasted for several days. The schedule‐induced polydipsia model of ethanol consumption in rats appears to be sensitive to the effects of drugs that inhibit ethanol intake in man.