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An automated descending rate‐intensity self‐stimulation paradigm: Usefulness for distinguishing antidepressants from neuroleptics
Author(s) -
Goldstein Jeffrey M.,
Malick Jeffrey B.
Publication year - 1983
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430030104
Subject(s) - haloperidol , chlorpromazine , imipramine , amphetamine , amitriptyline , medial forebrain bundle , stimulation , antidepressant , pharmacology , tricyclic , dextroamphetamine , psychology , anesthesia , medicine , neuroscience , hippocampus , striatum , alternative medicine , pathology , dopamine
Rats with medial forebrain bundle electrodes were trained to self‐stimulate during successive no‐cue periods in which the stimulating current remained constant for the first ten minutes and then decreased in small steps every two minutes for the next 30 minutes. Control response profiles generated in this manner were compared to drug dose‐response profiles. Tricyclic anti‐depressants (imipramine, amitriptyline) and neuroleptics (chlorpromazine, haloperidol) suppressed intracranial self‐stimulation (ICSS) responding in the fixed (F) and descending (DES) current periods. However, in combination with amphetamine, antidepressants potentiated amphetamine's effect in the DES periods only, whereas neuroleptics blocked amphetamine's effect in the DES periods. Both classes of drugs blocked amphetamine's effect in the F period. On the basis of these results, it is suggested that the ICSS model presented in this report can distinguish between antidepressant and neuroleptic drugs.