Premium
Air‐induced writhing: A rapid broad spectrum assay for analgesics
Author(s) -
VonVoigtlander Philip F.,
Lewis Richard A.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020609
Subject(s) - potentiator , analgesic , pharmacology , broad spectrum , chemistry , agonist , opioid , hot plate , medicine , receptor , combinatorial chemistry , biochemistry , mechanical engineering , engineering
The injection of air into the peritoneal cavity of rats produces reliable and quantifiable behavioral responses. These responses are blocked by compounds known to have analgesic properties, including opioid agonists, opioid agonist‐antagonists, cyclo‐oxygenase inhibitors, and amine potentiators. However, psychotropic agents were generally inactive at reasonable doses. The ability of this assay to identify a wide spectrum of analgesic agents in rats was superior to the hot plate, warm plate, and tail immersion assays.