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Effect of a new eburnamenine derivative (RU 24722) on EEG recovery in the conscious gerbil after cerebral ischemia
Author(s) -
Barzaghi Fernando,
Dragonetti Marco,
Robert Boissier Jacques
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020604
Subject(s) - ischemia , electroencephalography , gerbil , medicine , anesthesia , brain ischemia , psychiatry
The efficacy of a new eburnamenine derivative (RU 24722) on cerebral insufficiency was studied by evaluation of postischemic EEG recovery in the conscious gerbil. Ischemias of different durations were obtained by clamping both common carotids. This method required only brief anesthesia, thereby permitting the recording of EEG recovery in unanesthetized and unrestrained animals during the 24 hr following arterial occlusion. The EEG was analyzed by the Fast Fourier Transform. Mortality rate and clinical status were also evaluated. After a 5‐min ischemia the initial return of EEG was characterized by very high amplitude slow waves (1–2 Hz) and the EEG became normal 24 hr after ischemia. No mortality was observed. After a 10‐min ischemia the early recovery phase was characterized by a decrease in the power spectrum and a rebound of slow frequency waves after 2–4 hr. After 24 hr the EEG was not yet completely normal and 1 animal out of 10 died. A 15‐min ischemia killed 50% of the animals, and the EEGs of the survivors were abnormal even after 24 hr. Treatment with RU 24722 (10 mg/kg/s.c.) significantly improved the electrocortical recovery of gerbils submitted to a 10‐min ischemia. In this group the EEG was normalized 6 hr after ischemia in the same way as in the controls submitted to a 5‐min ischemia. These findings suggest that RU 24722 may have a therapeutic effect in cerebral insufficiency.