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Electrophysiological profile of neurotropics (hydergine, piracetam, pyritinol) in organic brain disease in the aged
Author(s) -
Zimmermann P.,
Fünfgeld E. W.,
Seidel R.,
Nischwitz W.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020509
Subject(s) - piracetam , electrophysiology , corneal reflex , electroencephalography , medicine , anesthesia , brainstem , reflex , psychiatry
Zimmermann, P., E.W. Füfgeld, R. Seidel, and W. Nischwitz : Electrophysiological profile of neurotropics (hydergine, piracetam, pyritionol) in organic brain disease in the aged. Drug Dev. Res. 2:481–488, 1982. The effects of neurotropics on brainstem and cortical neuronal activity were compared between three groups of patients suffering from chronic brain disease (arteriosclerotic or senile dementia). Hydergine (6–9 mg/day), piracetam (1,200 mg/day), or pyritinol (600 mg/day) were administered orally for 8wk. EEG power spectral analysis, visual evoked potentials (VEP) and bink reflexes were performed after an initial wash‐out period of 2 wk, 2 and 8 wk of neurotropic medication, and a final wash‐out period of 2 wk. EEG power spectra following hyderine show a significant decrease in slow alpha activity (7.5–10 Hz) and after pyritinol in the slow theta range (3–5 Hz) in the occipital region. In the piracetam group the power of the fast theta (5–7.5 Hz) and slow alpha activity decrease in the occipital region of the dominant hemisphere. Only during pyritinol medication do these signs of cerebral activation correlate with an increase in the amplitude of P 350 of VEP and of the R 2 component of the blink reflex.