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Effects of N‐substituted analogs of (−)‐α‐acetylmethadol and (−)‐α‐methadol on schedule‐controlled behavior
Author(s) -
McMillan D. E.,
Lattin D. L.,
Hardwick W. C.,
Greene D. L.,
Raible P. K.,
Richardson J. B.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020413
Subject(s) - methadone , (+) naloxone , pharmacology , narcotic , narcotic antagonists , chemistry , antagonist , agonist , psychology , anesthesia , medicine , receptor , biochemistry
The behavior of the pigeon maintained under a variable‐interval schedule of food presentation was used to compare the activity of four novel N‐substituted acetylmethadol and methadol analogs with that of methadone and (‐)‐α‐acetylmethadol (LAAM). All of the acetylmethadol and methadol analogs had narcotic agonist activity, as defined by the reversibility of their behavioral effects by naloxone. The effect of the N‐substituted analogs on variable‐interval responding was similar to that of methadone and LAAM, but all these compounds had a slower onset of action than methadone and a shorter duration of action than LAAM. None of the N‐substituted analogs showed narcotic antagonist activity when tested against methadone.