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Role of beta‐adrenergic receptors in the mechanism of action of second‐generation antidepressants
Author(s) -
Sethy Vimala H.,
Harris Douglas W.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020410
Subject(s) - amitriptyline , adrenergic receptor , diazepam , pharmacology , receptor , antidepressant , endocrinology , medicine , mianserin , mechanism of action , beta (programming language) , adrenergic , chemistry , serotonin , hippocampus , biochemistry , computer science , in vitro , programming language
The effect of chronic intravenous infusion of desmethylimipramine (DMI), amitriptyline, mianserin, bupropion, alprazolam, or diazepam on the density of beta‐adrenergic receptors in the rat cerebral cortex has been investigated in this study. DMI and amitriptyline significantly decreased the density of beta‐adrenergic receptors. Mainserin, bupropion, alprazolam, and diazepam had no significant effect on the density of beta‐adrenergic receptors. Results of this study indicate that mechanisms other than beta‐adrenergic receptors may be involved in the antidepressant activity of these drugs.