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Renal vasodilators and hypertension
Author(s) -
Ackerman Dennis M.,
Weinstock Joseph,
Wiebelhaus Virgil D.,
Berkowitz Barry
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020308
Subject(s) - vasodilation , stimulation , dopamine , medicine , renal blood flow , endocrinology , kidney , essential hypertension , dopamine receptor , receptor , adrenergic , pharmacology , blood pressure
SK&F 82526 is a potent renal vasodilator in dogs, monkeys, and hypertensive rats. It is orally active and has a specificity for the renal vasculature greater than dopamine. Its activity is owing, at least in part, to stimulation of renal dopamine receptors and has no effect on α‐ or β‐adrenergic receptors. This compound should be valuable in further examining the importance of renal blood flow in essential hypertension.