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The cardiovascular effects in dogs of two N‐Di‐Alkyl substituted analogs of dopamine and dopamine
Author(s) -
Maixner W.,
Long J. P.,
Wright C. B.,
Can J. G.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020206
Subject(s) - dopamine , heart rate , femoral artery , blood pressure , vascular resistance , medicine , anesthesia , pharmacology , chemistry , endocrinology
The cardiovascular effects of two N‐di‐alkyl substituted analogs of dopamine and dopamine were tested in the dog. Intravenous administration of N, N‐diethyldopamine (DEDA) decreased mean arterial pressure, heart rate, and mildly depressed cardiac output. Intravenously administered N, N‐dipropyldopamine (DPDA) decreased mean arterial pressure, heart rate, and total peripheral vascular resistance. Both compounds inhibited reflex sympathetic responses produced by a bilateral common carotid occlusion. Femoral artery injections of DEDA or DPDA produced biphasic responses. A transient increase in femoral bed vascular resistance was followed by a decrease in femoral bed vascular resistance sensitive to alpha adrenoceptor antagonism. In contrast to DEDA and DPDA, intravenously administered dopamine increased cardiac output and heart rate while reducing arterial pressure and total peripheral vascular resistance. Femoral artery injections of dopamine resulted in a dose‐dependent constrictor response which was antagonized by alpha receptor blockade. These data demonstrate that DEDA and DPDA induce different cardiovascular responses from dopamine.