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Isoxsuprine‐induced changes in maternal and fetal hemodynamics and fetal electroencephalogram
Author(s) -
Ayromlooi Jahangir,
Desiderio Denise M.,
Tobias Mitchell D.,
Leff Richard
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020108
Subject(s) - fetus , cerebral blood flow , metabolic acidosis , medicine , acidosis , anesthesia , hemodynamics , tachycardia , blood flow , gestation , endocrinology , pregnancy , biology , genetics
Isoxsuprine has been used in obstetrics in the treatment of premature labor. Its maternal and fetal effects were studied in five ewes with dated gestations of 137 ± 1.25 days (term approximately 147 days). Isoxsuprine (1 mg/min) was infused over a 30‐minute period to the anesthetized ewes while maternal and fetal blood pressures, uterine and fetal cerebral blood flows, and fetal brain function were studied. In addition, fetal and maternal acid‐base values and fetal cerebral metabolism were measured at baseline, 10, 20, 30, 45, and 60 minutes. Isoxsuprine caused maternal hypotension, tachycardia, and metabolic acidosis and temporary reduction of PO 2 without affecting oxygen saturation, O 2 content, or uterine blood flow. In the fetus hypotension, tachycardia, temporary metabolic acidosis, transient reduction in PO 2 and O 2 saturation occurred while PCO 2 , cerebral blood flow, brain glucose consumption, and the electroencephalogram remained essentially unchanged. Fetal pH, PO 2 , and O 2 saturation returned toward baseline values at the end of the experiment.