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Effects of analgesics, endorphins, and other drugs in a 3 H‐serotonin binding assay
Author(s) -
Gay David D.,
VonVoigtlander Philip F.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430020104
Subject(s) - pentazocine , nalorphine , serotonin , chemistry , pharmacology , endorphins , morphine , amitriptyline , monoaminergic , narcotic antagonist , antagonist , (+) naloxone , endocrinology , medicine , biochemistry , receptor
Analgesics of various classes, endorphins, and other psychotropic drugs were evaluated for activity in inhibiting 3 H‐serotonin binding to a soluble serotonin binding protein (SBP) isolated from rat brain. Morphine, leu‐endorphin, and the narcotic antagonist, nalorphine, effectively inhibited binding, while other analgesics, including codeine, methadone, pentazocine, beta‐endorphin, and enkephalins were inactive. Amitriptyline partially inhibited binding, while stimulants did not. Inhibition of serotonin binding to SBP does not appear to be characteristic of narcotic analgescis or any one therapeutic class of compounds.