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The action of clobazam and diazepam on computer‐assisted tests of muscle activity: Dynamometric and myogenic effects
Author(s) -
Schaffler K.,
Rimkus U.,
Hirschmann K.,
Arnold H.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010723
Subject(s) - clobazam , anxiolytic , diazepam , benzodiazepine , placebo , volunteer , muscle relaxant , sedative , medicine , pharmacology , anti anxiety agents , anesthesia , anxiety , receptor , alternative medicine , pathology , psychiatry , agronomy , epilepsy , biology
The benzodiazepines have both anxiolytic and sedative properties, and in order to assess the effects of the drugs on the complex activities of everyday life and working conditions multidimensional test procedures must be used. In this paper on‐line monitoring of the myogram and of force exerted during working conditions were used in an objective approach to the assessment of operational and myogenic drug effects. The study was carried out in ten healthy volunteers under double‐blind conditions. Each volunteer received a single dose of diazepam 10 mg and 20 mg, clobazam 20 mg and 40 mg, and placebo, each separated by a 7‐day washout period. After benzodiazepine administration signs of muscle fatigue were seen in dynamic workload conditions, with uneconomical recruitment of motor units and a decrease in absolute force. These changes were not seen in static measurements. A dose‐dependent separation in myogenic influence was detected with clobazam, which led to a more pronounced muscle effect for the lower dosage.