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Attenuation of chemically induced anxiogenic stimuli as a novel method for evaluating anxiolytic drugs: A comparison of clobazam with other benzodiazepines
Author(s) -
Lal Harbans,
Shearman Gary T.
Publication year - 1982
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010717
Subject(s) - anxiogenic , anxiolytic , pentylenetetrazol , clobazam , pharmacology , anticonvulsant , chemistry , psychology , medicine , anxiety , neuroscience , epilepsy , psychiatry
Male rats were trained to emit responses on one lever after they were injected with pentylenetetrazol and a different lever when injected with saline in order to obtain food reinforcement. It was shown that the pentylenetetrazol action, which served as a cue for appropriate response selection, was predictive of anxiogenic activity. This cue was blocked by anxiolytic drugs in a dose‐dependent manner but not by anticonvulsant or depressant drugs. This procedure was shown to reliably predict elicitation of anxiogenicity or its blockade.