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Prolonged treatment with the GABA agonist THIP increases dopamine receptor binding more than it changes dopaminergic behaviour in mice
Author(s) -
Christensen A. V.,
Hyttel J.
Publication year - 1981
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010310
Subject(s) - agonist , dopaminergic , haloperidol , chemistry , pharmacology , dopamine receptor , dopamine agonist , dopamine , endocrinology , receptor , medicine , biochemistry
To investigate the influence of the GABA‐agonist, THIP, (4,5,6,7‐tetrahydroisoxazolo [5,4‐c] pyridin‐3‐ol) on the striatal dopaminergic system in mice after repeated administration, THIP, cis(Z)‐flupentixol, or haloperidol were given alone or in combinations for 12 days. The binding of 3 H‐spiroperidol was greatly increased, and that of 3 H‐cis(Z)‐flupentixol was slightly increased after treatment with THIP alone. After repeated treatment with neuroleptics, only slight increases in the binding were seen. There was no additive effect when treatments with THIP and the neuroleptics were combined. Repeated administration of THIP did not induce changes in the ability of an acute dose of either haloperidol or cis(Z)‐flupentixol to antagonize methylphenidate‐induced stereotyped gnawing. The behavioural supersensitivity induced by chronic treatment with the two neuroleptics was not changed by concomitant treatment with THIP.