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The effects of colchicine derivatives on humoral antibody response in mice
Author(s) -
Trottier R. W.,
Fitzgerald T. J.
Publication year - 1981
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010308
Subject(s) - colchicine , antibody , pharmacology , immunosuppression , drug , antibody response , humoral immunity , antigen , immunology , immune system , chemistry , medicine
The effects of colchicine and two of its chemical derivatives (propyl and bromo substitutions on the acetamido group) were investigated on the sheep red blood cell (SRBC) humoral antibody response in mice. These drugs were shown to suppress SRBC antibody titres. Immunosuppression was dependent upon temporal relationships of antigen/drug administration, as well as on the dosage profile of the drugs. In these studies bromocolchicine was the most active agent tested. Possible pharmacologic mechanisms are discussed.