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A comparison of butyrophenone and tricyclic neuroleptics with narcotics in blocking withdrawal signs in rats continuously infused with morphine
Author(s) -
Hynes Martin D.,
Lal Harbans
Publication year - 1981
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010303
Subject(s) - butyrophenone , haloperidol , morphine , (+) naloxone , chlorpromazine , pharmacology , tricyclic , narcotic , narcotic antagonist , pimozide , physical dependence , trifluoperazine , anesthesia , chemistry , medicine , opioid , dopamine , receptor , calmodulin , calcium
Narcotic dependence was established in male rats by continuous infusion of morphine given in increasing concentrations. Termination of the morphine infusion resulted in the reliable occurrence of body shakes. Narcotic drugs, morphine, fentanyl, and methadone, blocked withdrawal body shakes in a dose‐dependent manner. The butyrophenone neuroleptics, haloperidol, benperidol, and azaperone, were also effective in reducing withdrawal body shakes at doses that do not produce side effects. Trifluoperazine and chlorpromazine, two tricyclic neuroleptics were effective in reducing withdrawal shakes only at high doses that produced side effects. The anti‐withdrawal action of morphine, haloperidol, benperidol, and azaperone but not of chlorpromazine and trifluoperazine was antagonized by naloxone.