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Excitatory effects of hydergine on intracranial self‐stimulation
Author(s) -
Poschel B. P. H.,
Ninteman F. W.
Publication year - 1981
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010209
Subject(s) - excitatory postsynaptic potential , stimulation , medial forebrain bundle , forebrain , medicine , anesthesia , hypothalamus , endocrinology , central nervous system , receptor , striatum , dopamine
The effect of Hydergine on intracranial self‐stimulation was tested in male albino Holtzman rats. The rats had monopolar electrodes implanted in the medial forebrain bundle of the posterior hypothalamus. Hydergine was given orally at 40 and 80 mg/kg. A dose‐dependent excitatory effect occurred which was rapid in onset, large, long‐lasting, and evidenced in acute trials of the drug. The results suggest that a major portion of Hydergine's action in aged patients is stimulatory and antidepressant in nature.