Premium
Thyroliberin (TRH)‐induced shaking behavior in rats: Inhibition by antinociceptive compounds
Author(s) -
Kruse Hansjoerg,
Moeller Juergen
Publication year - 1981
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010108
Subject(s) - apomorphine , chemistry , oxotremorine , tetrabenazine , hypoactivity , ed50 , chlorpromazine , pharmacology , serotonergic , hot plate test , reserpine , nociception , morphine , haloperidol , clonidine , analgesic , endocrinology , medicine , serotonin , agonist , dopamine , biochemistry , receptor , in vitro
The influence of 49 compounds, among them 12 analgesics, on “wet dog” shaking (WDS) induced by thyroliberin (TRH) in rats has been investigated. WDS was dose dependently reduced by all of the analgesics and by 20 of the other drugs. The following compounds were the most active (ED50 values in parentheses): clonidine (5.4 μg/kg), fentanyl (9.6 μg/kg), oxotremorine (21 μg/kg), apomorphine (0.25 mg/kg), amphetamine (0.30 mg/kg), tetrabenazine (0.38 mg/kg), morphine (0.78 mg/kg), chlorpromazine (1.0 mg/kg), and ergotamine (1.2 mg/kg). Both agonists and antagonists of noradrenergic, dopaminergic, serotonergic, and GABA‐ergic functions were inhibitors of WDS, and antinociceptive activity was shared by most of the effective drugs. Thus, WDS or head‐shaking induced by TRH must be considered to be an expression of headache rather than such other causes as heat gain mechanisms or tremor induction. Prevention of TRH‐induced WDS may be used as a test of analgesic activity.