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A comparison of the antidiarrheal and some other pharmacological effects of clonidine, lidamidine, and loperamide in the rat
Author(s) -
Lal Harbans,
Shearman Gary T.
Publication year - 1981
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.430010104
Subject(s) - loperamide , clonidine , pharmacology , medicine , endocrinology , chemistry , diarrhea
Clonidine, lidamidine, and loperamide each inhibited castor oil‐induced diarrhea in the rat. Clonidine and lidamidine, but not loperamide, also induced diuresis but at doeses above those producing antidiarrheal activity. Clonidine and lidamidine, but not loperamide, produced autonomic and central effects including piloerection, hypotonia, exopthalmus and ataxia at doeses similar to those producing antidiarrheal activity. These data suggest that only loperamide possesses selective antidiarrheal activity.