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Synergistic interaction between B vitamins and statins to counter nociception in rats
Author(s) -
Skiold LópezCanales Jorge,
Estefania RuizPedraza Paola,
Carolina GarcíaPaz María Paola,
Mery LópezMayorga Ruth,
Fernando CastilloHenkel Enrique,
Jair LozanoCuenca
Publication year - 2021
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21767
Subject(s) - nociception , rosuvastatin , pravastatin , atorvastatin , pharmacology , chemistry , statin , medicine , receptor , cholesterol
Evidence suggests that the antinociceptive activity of various drugs can be increased when administered in combination with B vitamins (BVs). The aim of this study was to examine the potential interaction between statins and BVs to counter nociception, the latter measured by the formalin test. Rats were orally administered atorvastatin (1, 3, 10 and 30 mg/kg), pravastatin (1, 3, 10 and 30 mg/kg), rosuvastatin (1, 3, 10 and 30 mg/kg), BVs (31, 56, 100 and 180 mg/kg) or calculated combinations of BVs with each drug. The effective dose 30 (ED 30 ) was calculated for each statin and BVs and subjected to isobolographic analysis, thus finding the ED 30 of the combinations. The antinociceptive experimental ED 30 values for BVs administered with atorvastatin, pravastatin or rosuvastatin were 1.53 ± 0.38, 6.74 ± 0.04 and 4.26 ± 0.39, respectively, being lower ( p < .05) than the corresponding theoretical ED 30 : 28.02 ± 2.20, 28.17 ± 2.20 and 29.86 ± 2.21. Since BVs likely boost the antinociceptive effect of statins, these combinations could possibly be advantageous in pain management.