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Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release
Author(s) -
Özkahraman Bengi,
Tamahkar Emel,
İdil Neslihan,
Kılıç Suloglu Aysun,
Perçin Işık
Publication year - 2021
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21747
Subject(s) - self healing hydrogels , chitosan , gelatin , hyaluronic acid , chemistry , cytotoxicity , controlled release , viability assay , drug delivery , ampicillin , nuclear chemistry , materials science , polymer chemistry , in vitro , nanotechnology , antibiotics , biochemistry , organic chemistry , medicine , anatomy
The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS‐G/HA‐NPs hydrogels after 5 days. Antibacterial performance of CS‐G/HA‐NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS‐G/HA‐NPs hydrogels compared with CS‐G group after 24 hr incubation. Consequently, the potential ability of CS‐G/HA‐NPs hydrogels as a controlled drug delivery system has been verified.