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Osteoarthritis: Prognosis and emerging therapeutic approach for disease management
Author(s) -
Kumar Amresh,
Palit Partha,
Thomas Sabu,
Gupta Gaurav,
Ghosh Parasar,
Goswami Rudra Prosad,
Maity Tapan,
Choudhury Manabendra
Publication year - 2021
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21741
Subject(s) - osteoarthritis , medicine , disease , crosstalk , bioinformatics , therapeutic modalities , intensive care medicine , pathology , alternative medicine , biology , physics , optics
Osteoarthritis (OA), a disorder of joints, is prevalent in older age. The contemporary cure for OA is aimed to confer symptomatic relief, consisting of temporary pain and swelling relief. In this paper, we discuss various modalities responsible for the onset of OA and associated with its severity. Inhibition of chondrocytes receptors such as DDR2, SDF‐1, Asporin, and CXCR4 by specific pharmacological inhibitors attenuates OA, a critical step for finding potential disease modifying drugs. We critically analyzed recent OA studies with an emphasis on intermediate target molecules for OA intervention. We also explored some novel and safe treatments for OA by considering disease prognosis crosstalk with cellular signaling pathways.