Nitroglycerin ameliorates liver injury and regulates adaptive immunity in mice | Zendy

Zhao Shuang | Zendy; Lu ZhongHua | Zendy; Cui JuanJuan | Zendy; Li Dong | Zendy; Zhu YiLing | Zendy; Gan JianHe | Zendy

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Nitroglycerin ameliorates liver injury and regulates adaptive immunity in mice

Author(s) -

Zhao Shuang,

Lu ZhongHua,

Cui JuanJuan,

Li Dong,

Zhu YiLing,

Gan JianHe

Publication year - 2020

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.21653

Subject(s) - malondialdehyde , carbon tetrachloride , liver injury , glutathione , medicine , pharmacology , alanine aminotransferase , chemistry , oxidative stress , enzyme , biochemistry , organic chemistry

This study aimed to assess the protective effect of nitroglycerin, a commonly used drug in cardiovascular diseases, on mice with acute liver injury induced by carbon tetrachloride (CCl 4 ). The mice were randomly divided into three groups: control, CCl 4 , and CCl 4 + nitroglycerin. They were killed at 0, 6, 12, 24, and 48 h after treatment. Blood and liver tissue samples were collected for analysis. Analysis of the amounts of serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST), hepatic glutathione (GSH), and malondialdehyde (MDA) showed that nitroglycerin protected against CCl 4 ‐induced acute liver injury. Liver histological analysis provided further evidence of the protective effect of nitroglycerin. Furthermore, we found that nitroglycerin suppressed the increase of T helper 17 (Th17) cells in CCl 4 ‐induced acute liver injury mice. The results indicate that nitroglycerin is a potential candidate for hepatic disease.

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