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Nitroglycerin ameliorates liver injury and regulates adaptive immunity in mice
Author(s) -
Zhao Shuang,
Lu ZhongHua,
Cui JuanJuan,
Li Dong,
Zhu YiLing,
Gan JianHe
Publication year - 2020
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21653
Subject(s) - malondialdehyde , carbon tetrachloride , liver injury , glutathione , medicine , pharmacology , alanine aminotransferase , chemistry , oxidative stress , enzyme , biochemistry , organic chemistry
This study aimed to assess the protective effect of nitroglycerin, a commonly used drug in cardiovascular diseases, on mice with acute liver injury induced by carbon tetrachloride (CCl 4 ). The mice were randomly divided into three groups: control, CCl 4 , and CCl 4 + nitroglycerin. They were killed at 0, 6, 12, 24, and 48 h after treatment. Blood and liver tissue samples were collected for analysis. Analysis of the amounts of serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST), hepatic glutathione (GSH), and malondialdehyde (MDA) showed that nitroglycerin protected against CCl 4 ‐induced acute liver injury. Liver histological analysis provided further evidence of the protective effect of nitroglycerin. Furthermore, we found that nitroglycerin suppressed the increase of T helper 17 (Th17) cells in CCl 4 ‐induced acute liver injury mice. The results indicate that nitroglycerin is a potential candidate for hepatic disease.