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Effects of different doses of atorvastatin, rosuvastatin, and simvastatin on elderly patients with ST‐elevation acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI)
Author(s) -
He Weifeng,
Cao Maolin,
Li Zhifeng
Publication year - 2020
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21651
Subject(s) - rosuvastatin , medicine , conventional pci , mace , percutaneous coronary intervention , simvastatin , atorvastatin , myocardial infarction , cardiology
Objective To conduct a randomized double‐blind prospective study to investigate effect of different doses of atorvastatin, rosuvastatin, and simvastatin on elderly patients with ST‐elevation AMI after PCI. Methods One hundred and ninety‐two AMI patients over 60 years old who underwent PCI were randomly divided into six groups: the low atorvastatin group, high atorvastatin group; low rosuvastatin group; high rosuvastatin group; low simvastatin group; high simvastatin group. Demographic data and clinical information as well as coronary angiography parameters were recorded. Plasma levels of CK‐MB, BNP, ALT, and TnI were measured at 12 hr, 24 hr, and 1 week after PCI. Major cardiovascular events (MACE) were recorded and analyzed using Kaplan–Meier (K‐M) curve. Results No significant differences were observed in angiographic and procedural characteristics. In all high dose groups, all levels of CK‐MB, BNP, ALT, and TnI were significantly lower. However, after 1 week of PCI, only CK‐MB, BNP, and TnI showed significant difference between high and low dose groups. Patients in high dose groups had significantly lower rates for surgical or percutaneous intervention, recurrence of angina, and rehospitalization. K–M curve analysis also showed cumulative incidence freedom time of overall MACE in high dose groups was significantly longer. No significant differences were found among different drugs with the same doses. Conclusion Patients with higher doses had lower level of CK‐MB, BNP, ALT, and TnI and lower occurrence of MACE after PCI.