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Natural products and their derivatives as multifunctional ligands against Alzheimer's disease
Author(s) -
Patil Pooja,
Thakur Ashima,
Sharma Abha,
Flora Swaran Jeet Singh
Publication year - 2020
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21587
Subject(s) - tacrine , curcumin , natural product , galantamine , pharmacology , resveratrol , chemistry , neuroinflammation , huperzine a , harmine , cholinergic , alzheimer's disease , disease , biochemistry , donepezil , neuroscience , medicine , dementia , acetylcholinesterase , biology , enzyme
Alzheimer's disease (AD), a complex neurodegenerative disorder causing multiple cellular changes including impaired cholinergic system, beta‐amyloid (βA) aggregation, tau hyperphosphorylation, metal dyshomeostasis, neuroinflammation, and many other pathways are involved in the pathogenesis of the disease. However, the exact cause of the disease is not known. Natural products such as flavonoids, alkaloids, resveratrol, and curcumin have multifunctional properties, and have drawn the attention of the researchers because these molecules are capable of interacting concurrently with the multiple targets of AD. Therefore, natural products and their derivatives with proven efficacy could be used in the management of the neurodegenerative disorders. This review focuses on the natural product based multitarget directed ligands like tacrine‐coumarin, tacrine‐huperzine A, harmine‐isoxazoline, berberine‐thiophenyl, galantamine‐indole, pyridoxine‐resveratrol, donepezil‐curcumin and their mode of action.