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Epigenetic treatment of dermatologic disorders
Author(s) -
Moos Walter H.,
Faller Douglas V.,
Glavas Ioannis P.,
Harpp David N.,
Kanara Iphigenia,
Pinkert Carl A.,
Powers Whitney R.,
Sampani Konstantina,
Steliou Kosta,
Vavvas Demetrios G.,
Kodukula Krishna,
Zamboni Robert J.
Publication year - 2019
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21562
Subject(s) - psoriasis , epigenetics , medicine , skin cancer , disease , damp , function (biology) , inflammation , cancer , bioinformatics , pharmacology , biology , dermatology , immunology , pathology , biochemistry , genetics , physics , meteorology , gene
Healthy skin protects us against a multitude of insults, but injured or maladapted skin can lead to infection, inflammation, or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and other plant and vegetable extracts, have shown utility in treating skin and related diseases as well as conditioning the skin to maintain its healthy function. Powerful agents targeting nuclear regulatory pathways continue to hold promise as new or repurposed therapies for a wide variety of ills and skin conditions. Epigenetic approaches that activate Nrf2 to effect detoxification, redox balance, DNA repair, and mitochondrial function are noteworthy. Some of the disease applications being actively investigated range from eczema and psoriasis to skin cancer and diabetes‐related wound healing to name just a few.