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Investigation of the antibacterial and antifungal activity of thiolated naphthoquinones
Author(s) -
Wellington Kevin W.,
Nyoka Nomgqibelo B. P.,
McGaw Lyndy J.
Publication year - 2019
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21512
Subject(s) - antimicrobial , candida albicans , minimum inhibitory concentration , staphylococcus aureus , microbiology and biotechnology , naphthoquinone , antibacterial activity , antibiotics , chemistry , minimum bactericidal concentration , amphotericin b , bacteria , biology , antifungal , organic chemistry , genetics
The WHO has stated that antibiotic resistance is escalating to perilously high levels globally and that traditional therapies of antimicrobial drugs are futile against infections caused by resistant microorganisms. Novel antimicrobial drugs are therefore required. We report in this study on the inhibitory activity of the 1,4‐naphthoquinone‐2,3‐bis‐sulfides and 1,4‐naphthoquinone sulfides against two bacteria and a fungus to determine their antimicrobial properties. The 1,4‐naphthoquinone sulfides have potent activity with a minimum inhibitory concentration (MIC) of 7.8 μg/mL against Staphylococcus aureus (Gram +ve), an MIC of 23.4 μg/mL against the fungus, Candida albicans , which was better than that of Amphotericin B (MIC = 31.3 μg/mL), and against Escherichia coli (Gram −ve) an MIC of 31.3 μg/mL was obtained. The 1,4‐naphthoquinone had an MIC of 11.7 μg/mL against S. aureus and the 1,4‐naphthohydroquinone also had the same activity against E. coli .Hit, Lead & Candidate Discovery