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Reaching toward underexplored targets in antibacterial drug design
Author(s) -
Jukič Marko,
Gobec Stanislav,
Sova Matej
Publication year - 2019
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21465
Subject(s) - mura , drug development , antimicrobial , pharmacology , antibacterial activity , drug , computational biology , biology , microbiology and biotechnology , bacteria , computer science , genetics , liquid crystal display , operating system
The increase of antimicrobial resistance necessitates the renewal and strong research involvement in antibacterial drug design. In the following work, we comment on the key approaches used in development of new antibacterials, focusing on intracellular therapeutic targets that have been so far mostly underexplored: the enzymes of the Mur pathway MurA to MurF. We identify common obstacles observed during research on MurA, MurB, and Mur ligases inhibitors and their development into potential antibacterial compounds, and discern several approaches and solutions to tackle the whole‐cell activity of designed compounds. Furthermore, we consolidate recent literature reports and encourage the further research on Mur enzymes.