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Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress‐Induced Behavioral and Biochemical Alterations in Mouse Brain
Author(s) -
Adebesin Adaeze,
Ajayi Abayomi M.,
Olonode Elizabeth O.,
Omorogbe Osarume,
Umukoro Solomon
Publication year - 2017
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21410
Subject(s) - tail suspension test , malondialdehyde , corticosterone , methyl jasmonate , imipramine , endocrinology , oxidative stress , medicine , neuroinflammation , behavioural despair test , chemistry , pharmacology , antidepressant , hippocampus , biochemistry , hormone , inflammation , alternative medicine , pathology , gene
Preclinical ResearchThe effects of methyl jasmonate (MJ; 5, 10, 20 mg/kg, i.p), a natural product widely used for the relief of stress, depression, and exhaustion on unpredictable chronic mild stress (UCMS)‐induced depression‐like behaviors in mice was assessed and compared to those of imipramine (IMP; 10 mg/kg, i.p). MJ and IMP were given 30 min before exposure to UCMS with the procedure repeated daily for 2 weeks; 24 h after the stress session, the tail suspension test (TST) and sucrose preference test were assessed. MJ decreased immobility time in the TST and reversed impaired intake of sucrose relative to the stressed control suggesting antidepressant‐like activity. MJ also reduced UCMS‐induced increases in corticosterone and MDA (malondialdehyde) levels and attenuated UCMS‐induced decreases in GSH and TNF‐α levels and SOD activity. These findings suggest that MJ attenuated UCMS‐induced depressive‐like behaviors through decreased levels of corticosterone and decreasing oxidative stress and neuroinflammation in mouse brain.Drug Dev Res 78 : 381‐389, 2017. © 2017 Wiley Periodicals, Inc.