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Do Circadian Rhythms Draw the Patterns of Sustained Mental Vigor and Ailment?
Author(s) -
Sharma Ashish,
Goyal Rohit
Publication year - 2016
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21342
Subject(s) - circadian rhythm , context (archaeology) , neuroscience , rhythm , dysfunctional family , biology , dark therapy , psychology , medicine , psychiatry , paleontology
Preclinical ResearchCircadian rhythms are fundamental processes in all cells that coordinate a variety of cellular functions related to a specific time of the day. Disruption of circadian rhythms markedly impacts homeostasis. In this Commentary, we present data that disruption of circadian rhythm may lead to the pathogenesis of neurodegenerative states. In this context, we further argue that there is an urgent need of developing new generations of compounds, chronobiotics, to modulate the molecular substrates of circadian timing system. Chronobiotics conceptually offer an effective way for restoration and protection from the consequences of the circadian disruption. We also briefly discuss whether dysfunctional circadian rhythms are a major driver of aging. Drug Dev Res 77 : 469–473, 2016. © 2016 Wiley Periodicals, Inc.