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Nociceptive Alteration by High Sucrose Diet in Hypoestrogenic Wistar Rats
Author(s) -
JaramilloMorales Osmar Antonio,
EspinosaJuárez Josué Vidal,
CoronaRamos Janette Nallely,
LópezMuñoz Francisco Javier
Publication year - 2016
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21320
Subject(s) - endocrinology , medicine , uric acid , nociception , hyperuricemia , insulin , hyperinsulinemia , adipose tissue , biology , insulin resistance , receptor
Preclinical ResearchObesity is a risk factor associated with alterations in pain perception. The aim of this study was to analyse a time‐course of nociceptive responses (plantar test) in hypoestrogenic rats after the induction of obesity. Animals (hypoestrogenic and naïve) received either a hypercaloric or regular diet for 24 weeks. Thermal nociception and body weight were measured during this period. At the 4th and 17th weeks after treatment, oral glucose tolerance, blood insulin levels, abdominal fat weight, and uric acid levels were measured. The hypoestrogenic rats on a high sucrose diet had higher body weight and abdominal fat weight than control rats. A biphasic response was observed in the ovariectomized group fed with sucrose with thermal latency being decreased in the fourth week. During weeks 12–18, thermal latency increased compared to that of the hypoestrogenic control. There were no differences in basal blood glucose levels at the 4th and 17th weeks; however, oral glucose tolerance, insulin, and uric acid levels were altered. This indicated that increased body weight and fat as well as alteration sin glucose tolerance, hyperinsulinemia and hyperuricemia, may be associated with the biphasic nociceptive response. Drug Dev Res 77 : 258–266, 2016. © 2016 Wiley Periodicals, Inc.