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Isobolographic Analysis of the Interaction Between Tapentadol and Ketorolac in a Mouse Model of Visceral Pain
Author(s) -
ZapataMorales Juan R.,
AragonMartinez Othoniel H.,
Adriana SotoCastro Tely,
AlonsoCastro Ángel J.,
CastañedaSantana Demian I.,
IsiordiaEspinoza Mario A.
Publication year - 2016
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21310
Subject(s) - tapentadol , ketorolac , ed50 , pharmacology , nociception , chemistry , acetic acid , analgesic , medicine , anesthesia , opioid , in vitro , receptor , biochemistry
Preclinical ResearchThe aim of this experimental assay was to assess the antinociceptive interaction between tapentadol and ketorolac in the acetic acid‐induced writhing model in mice. Tapentadol (5.62–31.6 mg/kg ip) or ketorolac (5.62–31.6 mg/kg ip) were administered 15 min before the acetic acid administration. The ED 50 values of the individual drugs were determined and different proportions (tapentadol–ketorolac in 1:1, 3:1, and 1:3) were assayed in combination in the writhing test. Isobolographic analysis and the interaction index demonstrated an antinociceptive synergistic interaction between tapentadol and ketorolac in all combination. Thus, the experimental ED 50 values were lower when compared with their theoretical ED 50 values. These data suggest that the tapentadol–ketorolac combination produces an antinociceptive synergistic interaction in the mouse acetic acid‐induced writhing model. Drug Dev Res 77 : 187–191, 2016. © 2016 Wiley Periodicals, Inc.