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Antinociceptive Activity of an Ethanol Extract of Justicia spicigera
Author(s) -
ZapataMorales Juan Ramón,
AlonsoCastro Angel Josabad,
Domínguez Fabiola,
CarranzaÁlvarez Candy,
Castellanos Luis Manuel Orozco,
MartínezMedina Rosa María,
PérezUrizar José
Publication year - 2016
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21307
Subject(s) - analgesic , sedative , nociception , pharmacology , ethanol , naproxen , traditional medicine , medicine , tail flick test , ketamine , hot plate , chemistry , anesthesia , biochemistry , alternative medicine , pathology , mechanical engineering , engineering , receptor
Preclinical ResearchThe aim of the present study was to evaluate the antinociceptive and sedative activity of an ethanol extract of Justicia spicigera an evergreen used in Mexican traditional medicine for the relief of pain, wounds, fever and inflammation. At 200 mg/kg po, the maximum dose examined, the ethanol extract of J. spicigera (JSE) had analgesic activity in mice in the acetic acid writhing test, the second phase of the formalin test and the tail flick test that was similar in efficacy to the NSAID, naproxen (150 mg/kg po). JSE was inactive in the hot plate test and and the ketamine‐induced sleeping time test; it had no sedative effects. These results show that the ethanol extract from the leaves of J. spicigera has antinociceptive effects in mice without inducing sedation. Drug Dev Res 77 : 180–186, 2016. © 2016 Wiley Periodicals, Inc.