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Does miRNA‐155 Promote Cyclooxygenase‐2 Expression in Cancer?
Author(s) -
Comer Brian S.
Publication year - 2015
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21276
Subject(s) - colorectal cancer , cyclooxygenase , microrna , mir 155 , regulator , cancer research , cancer , inflammation , medicine , epithelial–mesenchymal transition , mouse model of colorectal and intestinal cancer , biology , oncology , metastasis , enzyme , gene , biochemistry
Preclinical ResearchMicroRNA (miR)‐155 and cyclooxygenase (COX)‐2 are both elevated in numerous cancers including colorectal cancer. MiR‐155 enhances COX‐2 expression and is an established regulator of epithelial‐mesenchymal transition and inflammation. Inhibition of miR‐155 or COX‐2 exhibit similar negative effects on tumorigenicity. Thus, it is hypothesized that miR‐155 may be a promising target for antagonizing COX‐2 expression in colorectal and other cancers. Drug Dev Res 76 : 354–356, 2015. © 2015 Wiley Periodicals, Inc.