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Thalidomide Inhibits Adhesion Molecules in Experimental Acute Pancreatitis‐Associated Lung Injury
Author(s) -
Lv Peng,
Li HongYun,
Ji ShuSheng,
Li Wen,
Fan LiJuan
Publication year - 2015
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21237
Subject(s) - bronchoalveolar lavage , thalidomide , acute pancreatitis , pancreatitis , superoxide dismutase , malondialdehyde , pharmacology , glutathione peroxidase , medicine , cell adhesion molecule , lung , oxidative stress , endocrinology , chemistry , immunology , multiple myeloma
Preclinical ResearchThe study evaluated the effect of thalidomide on adhesion molecule expression in acute pancreatitis‐associated lung injury in rats. Acute pancreatitis was induced in rats by retrograde infusion of 5% sodium taurocholate into the bile‐pancreatic duct, and thalidomide (100 mg/kg) was given daily by intragastric route for 8 days before this treatment. Serum lipase (LPS), protein levels in bronchoalveolar lavage fluid (BALF), superoxide dismutase (SOD), glutathione peroxidase (GSHpx), and malondialdehyde (MDA) levels in lung were measured. Compared with the acute pancreatitis‐ group, lung histopathology, serum LPS, protein levels in BALF, SOD, GSHpx, and MDA levels, and the expression levels of intercellular adhesion molecule‐1 and E‐selectin mRNA and protein in rats given thalidomide were improved ( P < 0.01). Thus, thalidomide may reduce the expression of adhesion molecules via inhibition of oxidative stress to alleviate acute pancreatitis‐associated lung injury in a rat model. Drug Dev Res 76 : 24–30, 2015