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Synthesis of New Thiobarbituric Acid Derived Spiroheterobicyclic Compounds and Their Antimicrobial Activity
Author(s) -
Kaur Gurpreet,
Gupta Parul,
Harjai Kusum,
Singh Vasundhara
Publication year - 2014
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21172
Subject(s) - antimicrobial , thiobarbituric acid , thiourea , chemistry , staphylococcus epidermidis , potency , thio , urea , staphylococcus aureus , undecane , antibacterial activity , escherichia coli , pseudomonas aeruginosa , organic chemistry , microbiology and biotechnology , in vitro , antioxidant , bacteria , biochemistry , biology , lipid peroxidation , gene , genetics
Preclinical ResearchA series pf novel (7 S , 11 R )—substituted diphenyl‐2,4,8,10‐tetraazaspiro [5.5] undecane‐3‐thio‐1,5,9‐triones 4 a‐j and (7 S ,11 R )‐substituted diphenyl‐2,4,8,10‐tetraazaspiro[5.5] undecane‐3‐thio‐1,5 dione, 9‐thiones 5 a‐j were prepared using substituted aldehydes and urea/thiourea in the presence of thiobarbituric acid under solvent free, thermal and microwave conditions catalyzed by ecofriendly K ‐10 clay. The antibacterial potency of these compounds in vitro on the gram negative strains E scherichia coli and P seudomonas aeruginosa and gram positive strains S taphyllococcus aureus and S taphylococcus epidermidis was evaluated.