Synthesis of New Thiobarbituric Acid Derived Spiroheterobicyclic Compounds and Their Antimicrobial Activity | Zendy

Kaur Gurpreet | Zendy; Gupta Parul | Zendy; Harjai Kusum | Zendy; Singh Vasundhara | Zendy

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Synthesis of New Thiobarbituric Acid Derived Spiroheterobicyclic Compounds and Their Antimicrobial Activity

Author(s) -

Kaur Gurpreet,

Gupta Parul,

Harjai Kusum,

Singh Vasundhara

Publication year - 2014

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.21172

Subject(s) - antimicrobial , thiobarbituric acid , thiourea , chemistry , staphylococcus epidermidis , potency , thio , urea , staphylococcus aureus , undecane , antibacterial activity , escherichia coli , pseudomonas aeruginosa , organic chemistry , microbiology and biotechnology , in vitro , antioxidant , bacteria , biochemistry , biology , lipid peroxidation , gene , genetics

Preclinical ResearchA series pf novel (7 S , 11 R )—substituted diphenyl‐2,4,8,10‐tetraazaspiro [5.5] undecane‐3‐thio‐1,5,9‐triones 4 a‐j and (7 S ,11 R )‐substituted diphenyl‐2,4,8,10‐tetraazaspiro[5.5] undecane‐3‐thio‐1,5 dione, 9‐thiones 5 a‐j were prepared using substituted aldehydes and urea/thiourea in the presence of thiobarbituric acid under solvent free, thermal and microwave conditions catalyzed by ecofriendly K ‐10 clay. The antibacterial potency of these compounds in vitro on the gram negative strains E scherichia coli and P seudomonas aeruginosa and gram positive strains S taphyllococcus aureus and S taphylococcus epidermidis was evaluated.

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