Premium
Synthesis and Antimetastatic Effects of E ‐Salignone Amide Derivatives
Author(s) -
Wang HongLing,
Qin Nan,
Liu Jia,
Jin MeiNa,
Zhang Xiang,
Jin MeiHua,
Kong Dexin,
Jiang ShenDe,
Duan HongQuan
Publication year - 2014
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21157
Subject(s) - amide , chemistry , androsterone , stereochemistry , biological activity , biochemistry , pharmacology , in vitro , steroid , biology , hormone
Preclinical ResearchThe preparation of novel E ‐salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E ‐salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical 1 H NMR , 13 C NMR , and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA ‐ MB ‐231 cells by using a transwell assay. Comparing with the positive control, LY 294002, compounds 19b , 19d , and 19e exhibited significant inhibitory effects on the EGF ‐induced invasion of MB ‐ MDA ‐231 cells. Moreover, compound 19b also had antimigration effects in wound‐healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.