Synthesis and Antimetastatic Effects of   E  ‐Salignone Amide Derivatives | Zendy

Wang HongLing | Zendy; Qin Nan | Zendy; Liu Jia | Zendy; Jin MeiNa | Zendy; Zhang Xiang | Zendy; Jin MeiHua | Zendy; Kong Dexin | Zendy; Jiang ShenDe | Zendy; Duan HongQuan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis and Antimetastatic Effects of E ‐Salignone Amide Derivatives

Author(s) -

Wang HongLing,

Qin Nan,

Liu Jia,

Jin MeiNa,

Zhang Xiang,

Jin MeiHua,

Kong Dexin,

Jiang ShenDe,

Duan HongQuan

Publication year - 2014

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.21157

Subject(s) - amide , chemistry , androsterone , stereochemistry , biological activity , biochemistry , pharmacology , in vitro , steroid , biology , hormone

Preclinical ResearchThe preparation of novel E ‐salignone derivatives and their biological evaluation as potential antimetastatic agents is described. The E ‐salignone amide derivatives were prepared from epiandrosterone and androsterone, and characterized by analytical 1 H NMR , 13 C NMR , and mass spectrometry. The derivatives were evaluated for antimetastatic activity in MDA ‐ MB ‐231 cells by using a transwell assay. Comparing with the positive control, LY 294002, compounds 19b , 19d , and 19e exhibited significant inhibitory effects on the EGF ‐induced invasion of MB ‐ MDA ‐231 cells. Moreover, compound 19b also had antimigration effects in wound‐healing assay. Compound 19b may represent a novel antimetastatic agent for treating breast cancer.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research