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Vanilloid‐Like Agents: Potential Therapeutic Targeting of Platelets?
Author(s) -
Adams Murray J.,
Almaghrabi Safa Y.,
Ahuja Kiran D. K.,
Geraghty Dominic P.
Publication year - 2013
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21102
Subject(s) - trpv1 , chemistry , capsaicin , receptor , transient receptor potential channel , endogeny , cannabinoid receptor , pharmacology , platelet , biochemistry , medicine , agonist , biology
Preclinical ResearchCapsaicinoids are the “hot” compounds present in placental tissues of C apsicum fruits that are responsible for capsicum's pungency. Capsaicinoids belong to the broader class of vanilloids that activate the nonselective cation channel, transient receptor potential vanilloid‐1 ( TRPV1 ). Endogenous vanilloids include arachidonic acid derivatives that have different affinities for TRPV1 and are increasingly recognized as an important group of signaling molecules affecting tissue injury, pain, and inflammation. Furthermore, some endogenous vanilloids have high affinity for cannabinoid receptors ( CB1 and CB2 ), which are present in platelets. The most well‐known and widely studied plant‐derived vanilloid, capsaicin, is reported to have antiplatelet properties, but the mechanism of action is uncertain. This article will briefly review the mechanisms involved in platelet activation and aggregation, discuss the properties of vanilloids and their receptor, TRPV1 , and discuss whether the effects of vanilloids, and particularly capsaicinoids, on platelets may be exploited for therapeutic benefit.