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Nutritional Targets for Modulation of the Microbiota in Obesity
Author(s) -
Pimentel Gustavo D.,
Micheletti Thayana O.,
Pace Fernanda
Publication year - 2013
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21092
Subject(s) - gut flora , microbiome , obesity , steatosis , gut microbiome , biology , diabetes mellitus , human health , bioinformatics , physiology , medicine , endocrinology , immunology , environmental health
Preclinical ResearchThe gut microbiota is being increasingly appreciated by both clinical and research professionals as the human ancestral genome has undergone modification by the microbes that colonize the human body. The gut is now known to be a key metabolic organ that contains some 15 000 bacterial species that influence health and chronic diseases, the latter including obesity, type 2 diabetes, hepatic steatosis, and hypertension. Based on the potentially beneficial effects of nutrients, this review discusses how obesity disturbs the gut microbiota. Additionally, the main dietary nutrients known to modulate the intestine microbiome were highlighted.