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5‐ HT 1 and 5‐ HT 2 Receptors Are Involved in the Anxiolytic‐Like Effects of the Neuronal NOS Inhibitor TRIM in the Rat
Author(s) -
Tanyeri Pelin,
Mutlu Oguz,
Ulak Güner,
Akar Füruzan Yildiz,
Celikyurt Ipek Komsuoglu,
Erden Bekir Faruk
Publication year - 2013
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21074
Subject(s) - ketanserin , pharmacology , antagonist , anxiolytic , receptor antagonist , chemistry , cyproheptadine , elevated plus maze , 5 ht receptor , medicine , endocrinology , receptor , serotonin , biochemistry , anxiety , psychiatry
Preclinical ResearchTRIM , a selective neuronal NOS inhibitor, had anxiolytic effects in the elevated plus‐maze ( EPM ) test. The aim of the present study was to evaluate the involvement of serotonergic system in the anxiolytic‐like effect of TRIM in the EPM test, a widely used animal model of anxiety. The anxiolytic‐like effect of TRIM (50 mg/kg, i.p.) in adult Wistar albino male rats in the EPM test was antagonized by pretreatment with the 5‐ HT depleting agent; parachlorophenylalanine methyl ester (3 × 150 mg/kg i.p.) that inhibits 5‐ HT synthesis; methiothepin (0.1 mg/kg, i.p.), a nonselective 5‐ HT receptor antagonist; WAY 100635 (0.1 mg/kg i.p.), a selective 5‐ HT 1A receptor antagonist; GR 127935 (3 mg/kg i.p.), a selective 5‐ HT 1B/1D receptor antagonist; cyproheptadine (3 mg/kg i.p.), a 5‐ HT 2 receptor antagonist; or ketanserin (5 mg/kg i.p.), a 5‐ HT 2A/2C receptor antagonist. The anxiolytic‐like effects of TRIM thus appear to be mediated in part by 5‐ HT 1 and 5‐ HT 2 receptors.