Antileishmanial Activity of Natural Product‐Like Naphthoquinones | Zendy

Malerich Jeremiah P. | Zendy; Li Jinfang | Zendy; Joder Dallas | Zendy; Vieria Érica L. M. | Zendy; Keesen Tatjana S. L. | Zendy; Vaidyanathan Rajeev | Zendy; Gollob Kenneth J. | Zendy; Tanga Mary J. | Zendy

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Antileishmanial Activity of Natural Product‐Like Naphthoquinones

Author(s) -

Malerich Jeremiah P.,

Li Jinfang,

Joder Dallas,

Vieria Érica L. M.,

Keesen Tatjana S. L.,

Vaidyanathan Rajeev,

Gollob Kenneth J.,

Tanga Mary J.

Publication year - 2013

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.21067

Subject(s) - natural product , amphotericin b , chemistry , naphthoquinone , pharmacology , stereochemistry , structure–activity relationship , leishmania infantum , biological activity , antifungal , biochemistry , medicine , biology , microbiology and biotechnology , immunology , organic chemistry , leishmaniasis , in vitro , visceral leishmaniasis

Preclinical ResearchThe antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from B ignoniaceae is presented. Three structural series of compounds from a common biosynthetic pathway were evaluated against L eishmania major . Compound ( 15 ), an analog of the natural product pinnatal, was more active than amphotericin B against L . major . When tested against L . ( V iannia) braziliensis and L . infantum , compound 15 showed similar activity to amphotericin B .

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