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Antileishmanial Activity of Natural Product‐Like Naphthoquinones
Author(s) -
Malerich Jeremiah P.,
Li Jinfang,
Joder Dallas,
Vieria Érica L. M.,
Keesen Tatjana S. L.,
Vaidyanathan Rajeev,
Gollob Kenneth J.,
Tanga Mary J.
Publication year - 2013
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21067
Subject(s) - natural product , amphotericin b , chemistry , naphthoquinone , pharmacology , stereochemistry , structure–activity relationship , leishmania infantum , biological activity , antifungal , biochemistry , medicine , biology , microbiology and biotechnology , immunology , organic chemistry , leishmaniasis , in vitro , visceral leishmaniasis
Preclinical ResearchThe antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from B ignoniaceae is presented. Three structural series of compounds from a common biosynthetic pathway were evaluated against L eishmania major . Compound ( 15 ), an analog of the natural product pinnatal, was more active than amphotericin B against L . major . When tested against L . ( V iannia) braziliensis and L . infantum , compound 15 showed similar activity to amphotericin B .