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Synthesis of 4‐(Carbonyloxyphenyl)‐1,4‐Dihydropyridines as Potential Antihypertensive Agents
Author(s) -
Bansal Ranju,
Narang Gaurav,
Calle Carmen,
Carron Rosalia,
Pemberton Karen,
Harvey Alan L.
Publication year - 2013
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21056
Subject(s) - nifedipine , dihydropyridine , chemistry , vasodilation , dhps , pharmacology , coronary vasodilator , calcium channel , heart rate , antihypertensive drug , blood pressure , calcium , medicine , organic chemistry , malaria , immunology , plasmodium falciparum
Preclinical ResearchA series of novel symmetric and asymmetric 4‐(carbonyloxyphenyl)‐1,4‐dihydropyridines ( DHPs ) was synthesized and evaluated for calcium channel blocking, vasodilatory and antihypertensive properties. Some of these new DHPs displayed potent calcium channel blocking and good vasodilatory activities. Heart rate remained relatively constant in comparison with blood pressure changes in the case of these newly synthesized compounds, thereby decreasing the probability of reflex tachycardia, a major side effect of nifedipine. The most potent compound, ethyl methyl 4‐(3‐isopropylcarbonyloxyphenyl)‐2,6‐dimethyl‐1,4‐dihydropyridine‐3,5‐dicarboxylate (14c) exhibited antihypertensive activity comparable with the standard drug—nifedipine.