Premium
Exploring the Mysteries of Traditional Chinese Medicine Systematically by Expression Microarrays
Author(s) -
Cheng Feng
Publication year - 2012
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21042
Subject(s) - dna microarray , expression (computer science) , mechanism (biology) , personalized medicine , computational biology , genomics , gene expression , traditional chinese medicine , systems biology , functional genomics , bioinformatics , biology , data science , medicine , genetics , gene , computer science , alternative medicine , genome , pathology , epistemology , philosophy , programming language
Preclinical ResearchTraditional C hinese medicine often clashes with contemporary medicine because its principles and concepts are difficult to understand to scientists with a background in contemporary medicine. Therefore, more proof and explanation of traditional C hinese medicine at the molecular level are necessary. Expression microarrays, among the most important genomics techniques in modern systems biology, can simultaneously detect the expression levels of thousands of genes and identify related gene networks in biological systems. They may connect gene expression at the microlevel and system information at the macrolevel together. Expression microarrays may create building blocks to bridge traditional C hinese medicine and contemporary medicine. They may not only identify the action (or toxicological) mechanism or active ingredients of C hinese herbal medicine but also reveal the molecular mechanism of traditional C hinese medicine theories. The following is a brief overview of some applications of expression microarrays for traditional C hinese medicine studies.