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Application of Steroid Hormone Metabolomics in Search of Biomarkers in Clinical Research
Author(s) -
Kotłowska Alicja
Publication year - 2012
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21028
Subject(s) - metabolomics , hormone , profiling (computer programming) , endocrine system , steroid , computational biology , bioinformatics , steroid hormone , biology , computer science , endocrinology , operating system
Preclinical ResearchMetabolomics is a discipline that concentrates on the global assessment of endogenous metabolites present in a biological system. Metabolic profiling has been applied to cells, tissues, and/or biofluids in order to evaluate disease progress, broaden the understanding of the disorder, and to select potential biomarkers. Steroid hormones play an important role in the regulation of routine functions in the human body, and their measurement in biological samples is essential for the diagnosis of various endocrine disorders. The present overview describes various strategies and analytical techniques applied in metabolomic studies, particularly with reference to the steroid metabolic profiling useful for the search of novel biomarkers.