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Development of a Sulglycotide‐Loaded Oral Gel with Good Stability and Improved Gastric Ulcer Inhibition
Author(s) -
Cho Kwan Hyung,
Park YoungJoon,
Choi HanGon
Publication year - 2012
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21016
Subject(s) - chemistry , chromatography , phosphate buffered saline , oral administration , aqueous solution , polymer , chemical stability , pharmacology , organic chemistry , medicine
trategy, Management and Health Policy Preclinical ResearchTo develop a novel sulglycotide‐loaded oral gel with good stability and gastric ulcer inhibitory activity, the effect of pH and buffer capacity on the stability of sulglycotide in aqueous solution was investigated. Sulglycotide‐loaded gels were prepared with various mucoadhesive polymers, and their stability and gastric ulcer inhibitory activity in rats were evaluated. Sulglycotide was very unstable in acidic conditions of not more than pH 4.0. Buffer capacity affected the degradation of the drug by a small amount in the alkaline solutions. Among the sulglycotide‐loaded gels tested, those with carbopol gave excellent stability. The sulglycotide‐loaded gel with phosphate buffered solution (50 mM KH 2 PO 4 , pH 7.2) and carbopol improved gastric ulcer inhibition in comparison with the sample without carbopol. In particular, this sulglycotide‐loaded gel gave the drug content of 95%, with no changes in either viscosity or pH when maintained at 60°C for 4 weeks, inhibiting gastric ulcer formation by approximately of 70%. Thus, it has potential as an oral gel with good stability and excellent gastric ulcer inhibition.