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Neuropharmacological and Toxicity Evaluations of Ethanol Extract from R hodiola R osea
Author(s) -
MontielRuiz Rosa Mariana,
RoaCoria José Eduardo,
PatiñoCamacho Selene Isabel,
FloresMurrieta Francisco J.,
DécigaCampos Myrna
Publication year - 2012
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.21001
Subject(s) - toxicity , pharmacology , ethanol , chemistry , medicine , biochemistry , organic chemistry
trategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics Clinical Development Phases I‐III Regulatory, Quality, Manufacturing Postmarketing Phase IVR hodiola r osea is a popular medicinal plant that is commonly used as an adaptogen in folklore medicine in E urope and A sia due to its ability to increase an organism's resistance to physical, chemical and biological stress. The aim of this study was to determine the central nervous system activity and toxicity parameters of R . r osea . An ethanol extract from the roots of R . r osea was orally (p.o.) administered to mice (10–316 mg/kg); exploratory activity, anti‐anxiety, behavior, sodium pentobarbital‐induced hypnosis, antinociceptive effects, and pentylenetetrazole‐induced seizures were tested. The results from the experimental models tested showed a significant reduction in exploratory behavior and in the number of rearings and head dippings, but no change in the sedative‐hypnotic and anticonvulsant response with respect to vehicle. Moreover, R . r osea reduced the licking time in the formalin test. R . r osea was not toxic in A rtemia s alina and in mice. The present results confirm some preclinical and clinical studies that indicate stimulating, anxiolytic‐like effects and present new evidence of the antinociceptive effect of and very low risk of toxicity from R . r osea .