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Discovering molecular targets in cancer with multiscale modeling
Author(s) -
Wang Zhihui,
Bordas Veronika,
Deisboeck Thomas S.
Publication year - 2011
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20401
Subject(s) - in silico , computational biology , multiscale modeling , computer science , drug discovery , data science , bioinformatics , biology , biochemistry , gene
Multiscale modeling is being recognized increasingly as a promising research area in computational cancer systems biology. In the present review, exemplified by two pioneering studies, we attempt to explain why and how such a multiscale approach paired with an innovative cross‐scale analytical technique can be useful in identifying high‐value molecular therapeutic targets. This novel, integrated approach has the potential to offer a more effective in silico framework for target discovery and represents an important technical step toward systems medicine. Drug Dev Res 72: 45–52, 2011. © 2010 Wiley‐Liss, Inc.