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State‐of‐the‐art process for the safe synthesis of anticancer drugs
Author(s) -
Ammoscato Vince,
Wickenheiser Rebecca,
Henderson John,
Munk Stephen
Publication year - 2010
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20384
Subject(s) - drug , risk analysis (engineering) , drug development , process (computing) , anticancer drug , pharmacology , biochemical engineering , chemistry , computer science , business , medicine , engineering , operating system
Most cancer drugs are quite potent and represent a potential hazard to chemists conducting their synthesis. Chemical development teams must therefore integrate proper handing techniques for such compounds into their development plans. We describe the synthesis of the drug busulfan using barrier isolation technology. These systems are a general solution for the safe handling of many potent drugs, including those used to treat cancer. Drug Dev Res 71: 439–444, 2010. © 2010 Wiley‐Liss, Inc.