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Targeting the development of resveratrol as a chemopreventive agent
Author(s) -
Li NianGuang,
Shi ZhiHao,
Tang YuPing,
Yang JianPing,
Wang ZhenJiang,
Song ShuLin,
Lu TuLin,
Duan JinAo
Publication year - 2010
Publication title -
drug development research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.582
H-Index - 60
eISSN - 1098-2299
pISSN - 0272-4391
DOI - 10.1002/ddr.20380
Subject(s) - resveratrol , bioavailability , polyphenol , tumor promotion , pharmacology , drug development , cancer , tumor initiation , drug , chemistry , medicine , biochemistry , carcinogenesis , antioxidant
Tumor development consists of several separate, but closely linked, stages: tumor initiation, promotion, and progression. This long and complex process provides opportunities for intervention both in preventing cancer initiation and in treating the neoplasm during its premalignant stages. Resveratrol, a polyphenolic compound found in many plant species, including grapes, peanuts, and various herbs, has recently been investigated intensely for its cancer chemopreventive property. The present work is an overview of the chemopreventive mechanisms of resveratrol in anti‐initiation, anti‐promotion, and anti‐progression. These, together with the low toxicity of resveratrol, suggest promise for novel chemopreventive agents. However, the low bioavailability and rapid clearance of resveratrol from the circulation require the design of new resveratrol‐like chemopreventive agents, the structural modifications and the structure–activity relationship of which are also discussed in this review. Drug Dev Res 71:335–350, 2010. © 2010 Wiley‐Liss, Inc.