Effects of a novel class III antiarrhythmic agent, CPUY11018, on rat atrial fibrillation | Zendy

Guo Xiang | Zendy; Chen ChunLin | Zendy; Yang Qian | Zendy; Yin YueMiao | Zendy; You QiDong | Zendy; Tang YiQun | Zendy

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Effects of a novel class III antiarrhythmic agent, CPUY11018, on rat atrial fibrillation

Author(s) -

Guo Xiang,

Chen ChunLin,

Yang Qian,

Yin YueMiao,

You QiDong,

Tang YiQun

Publication year - 2010

Publication title -

drug development research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.582

H-Index - 60

eISSN - 1098-2299

pISSN - 0272-4391

DOI - 10.1002/ddr.20375

Subject(s) - atrial fibrillation , depolarization , acetylcholine , patch clamp , fibrillation , chemistry , medicine , cardiology , anti arrhythmia agents , pharmacology , electrophysiology

CPUY11018 has anti‐atrial fibrillation (AF) effects in rats. The effects of CPUY11018 on the transient outward K + current ( I to ) and ultra‐rapid delayed rectifier K + current ( I Kur ) were studied using whole‐cell patch clamp techniques and an acetylcholine (ACh)‐CaCl 2 induced AF model. CPUY11018 inhibited I to and I Kur in a concentration‐dependent manner with IC 50 values of 18.5 and 1.7 µM, respectively. Inhibition was independent of the depolarizing voltage. In the AF ACh‐CaCl 2 model, AF duration was effectively shortened after treatment with 5 mg/kg CPUY11018 for 4 days. These results indicate that CPUY11018 is effective in treating AF partly by blocking I to and I Kur . Drug Dev Res 71, 2010. © 2010 Wiley‐Liss, Inc.

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