Research Library

Premium Effects of a novel class III antiarrhythmic agent, CPUY11018, on rat atrial fibrillation
Guo Xiang,
Chen ChunLin,
Yang Qian,
Yin YueMiao,
You QiDong,
Tang YiQun
Publication year2010
Publication title
drug development research
Resource typeJournals
PublisherWiley Subscription Services
Abstract CPUY11018 has anti‐atrial fibrillation (AF) effects in rats. The effects of CPUY11018 on the transient outward K + current ( I to ) and ultra‐rapid delayed rectifier K + current ( I Kur ) were studied using whole‐cell patch clamp techniques and an acetylcholine (ACh)‐CaCl 2 induced AF model. CPUY11018 inhibited I to and I Kur in a concentration‐dependent manner with IC 50 values of 18.5 and 1.7 µM, respectively. Inhibition was independent of the depolarizing voltage. In the AF ACh‐CaCl 2 model, AF duration was effectively shortened after treatment with 5 mg/kg CPUY11018 for 4 days. These results indicate that CPUY11018 is effective in treating AF partly by blocking I to and I Kur . Drug Dev Res 71, 2010. © 2010 Wiley‐Liss, Inc.
Subject(s)acetylcholine , anti arrhythmia agents , atrial fibrillation , biochemistry , cardiology , chemistry , depolarization , electrophysiology , fibrillation , ic50 , in vitro , medicine , patch clamp , pharmacology
SCImago Journal Rank0.582

Seeing content that should not be on Zendy? Contact us.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here