Premium Effects of a novel class III antiarrhythmic agent, CPUY11018, on rat atrial fibrillationPremium
Author(s)
Guo Xiang,
Chen ChunLin,
Yang Qian,
Yin YueMiao,
You QiDong,
Tang YiQun
Publication year2010
Publication title
drug development research
Resource typeJournals
PublisherWiley Subscription Services
Abstract CPUY11018 has anti‐atrial fibrillation (AF) effects in rats. The effects of CPUY11018 on the transient outward K + current ( I to ) and ultra‐rapid delayed rectifier K + current ( I Kur ) were studied using whole‐cell patch clamp techniques and an acetylcholine (ACh)‐CaCl 2 induced AF model. CPUY11018 inhibited I to and I Kur in a concentration‐dependent manner with IC 50 values of 18.5 and 1.7 µM, respectively. Inhibition was independent of the depolarizing voltage. In the AF ACh‐CaCl 2 model, AF duration was effectively shortened after treatment with 5 mg/kg CPUY11018 for 4 days. These results indicate that CPUY11018 is effective in treating AF partly by blocking I to and I Kur . Drug Dev Res 71, 2010. © 2010 Wiley‐Liss, Inc.
Subject(s)acetylcholine , anti arrhythmia agents , atrial fibrillation , cardiology , chemistry , depolarization , electrophysiology , fibrillation , medicine , patch clamp , pharmacology
Language(s)English
SCImago Journal Rank0.582
H-Index60
eISSN1098-2299
pISSN0272-4391
DOI10.1002/ddr.20375
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